Weight change therapy as a potential treatmentfor end-stage ovarian carcinoma

Unusual or unexpected effect of treatment
The aim of this case report is to present the results of treatment of end-stage ovarian carcinoma in a 41-year
old women using weight loss therapy.
We describe the case of a female aged 41 years with epithelial invasive ovarian cancer of III–IV stage, T3

Concurrent diseases were: abdominal carcinomatosis; hepatomegaly; ascites; condition after laparocentesis and
skin-abdominal fistula; condition after 6 courses of neo-adjuvant polychemotherapy; hypertension II stage, risk
factor of 3–4; dyslipidemia; and metabolic syndrome. A weight loss method based on a very-low-calorie diet
and physical activity was used. Body weight was reduced from 74 kg to 53 due to loss of adipose tissue after 6
months of therapy. At the same time, the percentages of water and muscle tissue were increased significantly.
While overweight was reducing, clinical, laboratory, and instrumental results were improving. As a result of the
weight loss therapy, about »100 mm-sized ovarian cancer was transformed into smaller-sized ovarian cysts.
An analgesic effect was also achieved without use of narcotic or non-narcotic analgesics. These cyto-reversible
processes were documented by laboratory and instrumental data.
The mechanisms behind these differences remain to be elucidated. Future research with a larger study cohort
and longer follow-up is needed to further investigate the role of caloric restriction diet in cancer cell changes
in ovarian cancer.